Amerigo Scientific has gained rich expertise in investigating hematopoietic progenitors, and is proud to introduce our related products to our clients, to support their research projects.
Hematopoietic progenitors, aliases hematopoietic stem cells (HSCs) or hematopoietic progenitor cells (HPCs), are multipotent and regenerative cells that reside within blood and bone marrow, playing key roles in hematopoiesis. Hematopoietic progenitors are round, non-adherent, with a low cytoplasm-to-nucleus ratio, possessing the potential to differentiate into any mature cell type within the hematopoietic system, including red blood cells that carry oxygen, white blood cells that fight infections, and platelets that help stop bleeding.
Fig.1 Overview of normal human hematopoiesis.Distributed under CC-BY-SA 3.0, without modification, from Wiki
Hematopoietic progenitors can be divided into 3 subsets:
These types of hematopoietic progenitors differentiate and finally establish the peripheral effector cell populations in different lineages, like B cells or T cells in the lymphoid lineage and neutrophils or erythrocytes within the myeloid lineage.
The hematopoietic system provides a numeric cellular output and generates a variety of cell types, meeting the various needs of organisms, as well as holding the potential danger of malignant transformation. These facts underscore the significance of strict control on hematopoietic progenitors, which are intensively regulated by multiple neighbor cells, including mesenchymal stem cells (MSCs), endothelial cells, osteoblasts, megakaryocytes (MKs), macrophages, adipocytes, lymphoid cells, and nerve fibers. There is an intricate regulation network involved with a variety of cell markers, receptors, and signaling pathways between these cells and hematopoietic progenitors within the bone marrow, exerting effect on multiple processes of the latter, including quiescence, mobilization, proliferation, differentiation, survival, and self-renewal.
Here we list some of the main molecules and signaling pathways in the regulatory network:
| Molecules/Receptors on Hematopoietic Progenitors | CXCL12/CXCR4, SCF/KIT, TGF-β/TGFBR1, Osteopontin/CD44, Angiopoietin 1/TIE2, VCAM-1/VLA4, G-CSF or CSF3/CSF3R, M-CSF or CSF1/CSF1R, TPO/MPL, IGF-1/IGF1R, Pleiotrophin/RPTPZ1, Jagged-1/NOTCH, EGF/EGFR, DARC/CD82, CXCL4/CXCR3B, etc. |
| Signaling Pathways | Wnt signals, Notch signals, BMP4 signals, TGF-β1/Smad signaling pathway, CXCL12/CXCR4 axis, p38 MAPK-dependent pathway, AKT signals, PML–PPAR-δ–FAO signaling, AMPK signals, mTOR pathway, NF-kB pathway, FOXO pathway, NRF2 pathway, NOX pathway, etc. |
Fig.2 Cellular and selected molecular components of the hematopoietic progenitors (HSC) niche.1
As a leader in antibody research and development, Amerigo Scientific has gained rich knowledge and resources in research areas including hematopoietic progenitors, as well as the associated genes, cell markers, and pathways. We are proud to introduce our antibody products and related services for various applications to our esteemed clients around the world, assisting in your investigation of hematopoiesis. Please feel free to for more information.
Reference
Browse Products by Target Initial
