The Major histocompatibility complex (MHC) is a group of cell surface proteins that are responsible for presenting antigens to T cells, which are a key component of the immune response. When the T cell receptor (TCR) interacts with the MHC-peptide complex, it triggers a series of signals that ultimately activate the T cell and initiate an immune response. MHC genes are highly polymorphic, meaning that individuals within a population can have different alleles of MHC genes, resulting in different antigen presentation capabilities. This diversity in MHC genes is crucial for the immune system to be able to recognize and respond to a wide range of pathogens.
The MHC consists of two main classes of proteins: MHC class I and II. MHC class I proteins are expressed on the surface of virtually all cells in the body and present antigens originating from within the cell, such as tumor antigens. On the other hand, MHC class II proteins are predominantly located on immune cells like dendritic cells, macrophages, and B cells, presenting antigens from extracellular sources like bacteria or viruses.
Amerigo Scientific offers a range of MHC complex antibody products to researchers for assessment of MHC expression, function, and interactions. These antibodies are designed to target the MHC complex in various immunological research applications. Our MHC complex antibody products feature high specificity, enhanced sensitivity, and reliable performance. Our team also provides comprehensive technical support to help researchers effectively utilize these antibodies in their studies. Our MHC complex antibody products are widely used in research to study MHC expression levels, antigen presentation, and T-cell activation.
We offer MHC complex antibodies with diverse conjugation options, such as fluorescent dyes, enzymes, or biotin to suit different research needs and applications. We also provide customization options for our antibody products, allowing researchers to request specific conjugations or modifications based on their requirements. These antibodies are valuable tools in various experimental techniques, including immunoprecipitation, WB, ELISA, and immunofluorescence microscopy. Please let us know your specific requirements, and we will be happy to assist you in finding the right antibody product for your assay needs.
| MHC Class | HLA Type | Target |
| MHC-I | HLA-A | HLA-A |
| HLA-A | ||
| HLA-A1 | ||
| HLA-A2 | ||
| HLA-B | HLA-B | |
| HLA-B | ||
| HLA-C | HLA-C | |
| HLA-C | ||
| HLA-AB | HLA-A/HLA-B | |
| HLA-ABC | HLA-A/HLA-B/HLA-C | |
| HLA-A/HLA-B/HLA-C | ||
| HLA-E | HLA-E | |
| HLA-E | ||
| HLA-F | HLA-F | |
| HLA-G | HLA-G | |
| MHC II | HLA-D | HLA-D |
| HLA-D | ||
| HLA-DRA | ||
| HLA-DQ | ||
| HLA-DP |
| MHC Class | Target |
| MHC-I | H-2K |
| H-2 MHC class I | |
| H-2 MHC class I | |
| MHC II | I-A/I-E |
| I-A/I-E | |
| MHC II |
