The cytoskeleton constitutes a sophisticated network of interconnected protein filaments within the cytoplasm of cells. In eukaryotes, this dynamic network spans the entire cell. The cytoskeleton is responsible for maintaining internal organization and cell shape. In addition, the cytoskeleton provides mechanical support, allowing cells to execute their functions of movement and division. To delve deeper into the mysteries of this dynamic network, Amerigo Scientific offers a comprehensive range of cytoskeleton marker-related antibody products-precision tools designed to illuminate the intricate architecture of the cellular skeleton.
As an integral part of cell structure, cytoskeleton proteins can perform multiple functions. First, the cytoskeleton provides mechanical support to cells to maintain their normal morphology. Second, cytoskeleton proteins serve as crucial factors affecting cell polarity, motility, invasiveness, and growth. In addition, cytoskeleton proteins are also involved in intracellular signal transduction and transport. Importantly, cytoskeleton proteins are closely linked to the proliferation and invasion of tumor cells. Therefore, in recent years, cytoskeleton proteins have gradually emerged as potential markers for tumor progression and metastasis.
Fig.1 The central roles of the cytoskeleton.1
The dynamic network of the eukaryotic cytoskeleton is composed of three types of protein fibers, intermediate filaments (IFs), microtubules (MTs), and microfilaments (MFs). Evidence reveals that IF, MT, and MF play interrelated roles in tumor cell migration and metastasis.
IFs are very stable elements that constitute the suitable skeleton of the cell. IFs can anchor the nucleus and position it in the right place. In addition, IFs give cells the properties of elasticity and the ability to withstand tension.
MTs are composed of α/β tubulin polymers. MTs play a crucial role in regulating both cell motility and intracellular transport. Evidence reveals that alterations in MTs expression are closely associated with poor prognosis and tumor progression.
MFs, also known as actin filaments, are a vital component of the cytoskeleton. Accumulating evidence shows that MFs are closely related to a variety of cellular activities, including cell motility, cytokinesis, endocytosis and exocytosis, cell contractility, and cell shape change.
The PI3 kinase-Akt and Rho-Rock pathways are crucial targets for cytoskeleton-dependent control. The cytoskeleton is involved in regulating the intensity and duration of signals through multiple mechanisms. Notably, these signaling pathways are tightly linked to the regulation of cytoskeletal properties.
Some critical cytoskeletal marker targets are listed in the table below:
|
|
|
|
|
|
|
|
|
|
|
|
At Amerigo Scientific, a variety of antibodies targeting cytoskeletal markers are available. We look forward to empowering your research with the precision and reliability of our cytoskeleton marker-related antibody products. Contact our experts for more details on cytoskeletal marker antibodies.
Reference
Browse Products by Target Initial
