Mesenchymal Stem Cell related Antibody Products

With abundant experience and an available technical support team, Amerigo Scientific is proud to introduce our mesenchymal stem cells related products to our clients.

Overview of Mesenchymal Stem Cells

Mesenchymal stem cells (MSC) are a type of non-hematopoietic fibroblast-like cells widely distributed in the bone marrow (BM), adipose tissue, embryonic placenta, liver, umbilical cord blood, amniotic fluid, and other tissues. MSCs possess the multipotency to differentiate to osteocytes, adipocytes, chondrocytes, and other lineages. Besides differentiation capacity, MSCs in BM are also able to inhibit functions of most adaptive immune cells such as the proliferation of T cells, B cells, and NK cells, exerting a wide range of immunosuppressive and immunomodulatory effects.

Considering the capability to differentiate into endothelial cells and immunomodulatory properties, MSCs are widely utilized for autologous cell transplantation, providing environmental support for tissue regeneration.

Fig.1 MSC displaying typical ultrastructural characteristics.Distributed under CC BY 3.0, without modification, from Wiki

Clinical Significance of MSCs

MSCs have many ideal properties for the treatment of a broad spectrum of diseases, including autoimmune diseases, inflammatory diseases, degenerative diseases, and cancers. For autoimmune diseases, MSCs have been evaluated and applied in therapies against cardiovascular diseases, bone and cartilage repair, spinal cord injury, graft versus host disease, Crohn's disease, systemic lupus erythematosus, multiple sclerosis, and systemic sclerosis.

In addition, since MSCs are equipped with immunomodulation capacity and tumor-homing properties, exhibiting significant relevance for cell-based therapies in cancer treatment. MSCs with genetic modifications can deliver anti-tumor agents to tumor sites. In preclinical and clinical studies, MSCs have been recognized and investigated as vectors of oncolytic viruses and cytokines. A study has revealed that the MSCs in BM infected with an oncolytic adenovirus are tolerated in patients with relapsed/refractory pediatric solid tumors and result in disease stabilization in 2 of 9 patients, indicating the safety and therapeutic effects of the MSC-based therapy. Another clinical trial evaluates the efficacy and safety of MSCs expressing thymidine kinase of the herpes simplex virus (HSV-Tk), in patients with gastrointestinal or hepatopancreatobiliary adenocarcinoma in advanced, recurrent, or metastatic cases.

Regulation on MSCs in Cancers

Interactions between MSCs and tumors are intensively mediated by an intricate network of signaling pathways, resulting in induction or inhibition of cancer progression and metastasis. Human MSCs generally express markers including CD73, CD90, and CD105, while other surface markers of MSCs are slightly different according to the different tissues they are located. Besides, MSCs have been demonstrated to positively or negatively participating in regulation on multiple signaling pathways (as summarized in Fig.2) essential in cancer development, modulating the initiation and progression of cancers. Deep exploration of the regulation network between MSCs and cancers can provide strategies for MSCs-based anticancer therapies.

Fig.2 Schematic representation of the signaling pathways involved in the crosstalk between MSC and tumor.¹

Amerigo Scientific is dedicated to providing resources to our global clients in various research areas, including mesenchymal stem cells, as well as the associated cell markers and signaling pathways. We also offer reliable antibody products and related services for a wide range of applications, helping you in studying MSCs. Please feel free to contact us for more information.