Full Name: Glycoprotein A33
BACKGROUND: GPA33 is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.
Synonyms: A33; cell surface A33 antigen; glycoprotein A33 (transmembrane); transmembrane glycoprotein A33
Research Areas: Cancer
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