SLAMF6

Full Name: SLAM Family Member 6

BACKGROUND: The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

Synonyms: SLAMF6; SLAM family member 6; KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000; NTBA receptor; NK-T-B-antigen