Full Name: Clostridium botulinum Non-toxin haemagglutinin HA70
BACKGROUND: The hemagglutinin (HA) component of the progenitor toxin protects the structural integrity of botulinum neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host.
The HA component is involved in binding to the upper small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties (Probable). Whole protein and the HA-53 chain (but not the HA-22-23 chain) bind to bovine mucin; if the mucin is pretreated with neuraminidase (removes the terminal sialic acid of glycoconjugates) mucin binding is decreased.
Synonyms: C. botulinum HA70; C. botulinum haemagglutinin HA70
Research Areas: Microbiology
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