NOTCH3

NOTCH3

Target Overview

Full Name: Notch 3

BACKGROUND: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Synonyms: CADASIL; CADASIL1; CASIL; IMF2; LMNS

Research Areas: Cancer

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Amerigo scientific offers a comprehensive range of antibodies targeting NOTCH3. Use the filter to find the NOTCH3 antibody that best fits your needs.

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Catalog: ASPC1296
Target : NOTCH3
Host Species : Mouse
Species Reactivity : Human
Application : Immunohistochemistry, Flow Cytometry, Western Blot
For Research Use Only.

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