Full Name: Japanese encephalitis virus Envelope protein
BACKGROUND: Like other flaviviruses, JEV1 contains a single-stranded RNA genome of 11 kb in size. The virion of JEV contains three structural proteins, a 12-kDa nucleocapsid or core protein, a 8-kDa non-glycosylated membrane protein, and a 53kDa glycosylated envelope protein (E), as well as seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5). The E protein is the dominant antigen in eliciting neutralizing antibodies and plays an important role ininducing immunologic responses in the infected host. Structural elements of the E protein are also involved in viral attachment, fusion, penetration, hemagglutination, host range and cell tropism, and virus virulence and attenuation.
Synonyms: E protein; Envelope protein; JEV E
Research Areas: Microbiology
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