AGR2

Full Name: Anterior Gradient 2, Protein Disulphide Isomerase Family Member

BACKGROUND: Anterior gradient protein 2 homolog (AGR-2), also known as secreted cement gland protein XAG-2 homolog, is a protein that in humans is encoded by the AGR2 gene. Anterior gradient homolog 2 was originally discovered in Xenopus laevis. In Xenopus AGR2 plays a role in cement gland differentiation, but in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response, cell migration, and cell transformation. However, there have been other observations that AGR2 can repress growth and proliferation.

Synonyms: AGR2; anterior gradient 2, protein disulphide isomerase family member; AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-11