Anti-ERBB2 Monoclonal Antibody (FRP5)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC139	Anti-ERBB2 Antibody (FRP5)	Mouse IgG2a, Kappa	None	$460	In stock	Add
ASPC139-P	Anti-ERBB2 Antibody (FRP5), PE	Mouse IgG2a, Kappa	PE	$1,180	2-3 weeks	Add
ASPC139-A	Anti-ERBB2 Antibody (FRP5), APC	Mouse IgG2a, Kappa	APC	$980	2-3 weeks	Add
ASPC139-H	Anti-ERBB2 Antibody (FRP5), HRP	Mouse IgG2a, Kappa	HRP	$600	2-3 weeks	Add
ASPC139-B	Anti-ERBB2 Antibody (FRP5), Biotin	Mouse IgG2a, Kappa	Biotin	$680	2-3 weeks	Add

Anti-ERBB2 Monoclonal Antibody (FRP5)
- Product Description:
  
  The FRP5 antibody is an agonist antibody that specifically binds to the human ERBB2 extracellular domain. HER2 is a member of the ERBB family of receptor tyrosine kinases and plays a critical role in cell growth, survival, and differentiation.
  
  Applications:
  
  Agonist, Immunoprecipitation, Enzyme-Linked Immunosorbent Assay, Flow Cytometry
  
  Source:
  
  Mouse
  
  Target:
  
  ERBB2
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human HER2 extracellular domain
  
  Immunogen:
  
  SKBR3 cells
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  FRP5
  
  Isotype:
  
  Mouse IgG2a, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ERBB2 Monoclonal Antibody (FRP5) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ERBB2

Protein Name

Receptor tyrosine-protein kinase erbB-2

Molecular Family

Adhesion Molecules, CD Molecules

Introduction

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Alternative Names

Erb-B2 Receptor Tyrosine Kinase 2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; Tyrosine Kinase-Type Cell Surface Receptor HER2; Neuro/Glioblastoma Derived Oncogene Homolog; Human Epidermal Growth Factor Receptor 2; Metastatic Lymph Node Gene 19 Protein; Proto-Oncogene C-ErbB-2; Proto-Oncogene Neu; EC 2.7.10.1; P185erbB2; MLN 19; HER2; NGL; NEU

Gene ID

2064

UniProt

P04626

Related Disease

Glioma (GLM)

Subcellular Location

Nucleoplasm,Plasma membrane,Cytosol

Tissue Specificity

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Cell Type

Leukemia