VTCN1

Full Name: V-Set Domain Containing T Cell Activation Inhibitor 1

BACKGROUND: This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: B7-H4; B7H4; B7S1; B7X; B7h.5; PRO1291; VCTN1