1,3,4,5-Tetramethyl-2-[(2-oxopropyl)thio]imidazolium chloride

1,3,4,5-Tetramethyl-2-[(2-oxopropyl)thio]imidazolium chloride

Catalog Number:
I001055231ZED
Mfr. No.:
T101
Price:
$853
  • Size:
    10 mg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • T101 (L-682.777) is a good blocker of tissue transglutaminase and coagulation factor XIIIa. Both enzymes are inhibited with an IC50 of about 0.25 μM.

          Please contact us at for specific academic pricing.

          More Details

          Zedira
      • Properties
        • Molecular Weight
          248,77
          Storage
          Store at -20°C

          * Intended for research use only, not for use in human, therapeutic or diagnostic applications.

      • Applications
        • Application
          FXIII Inhibitors
          Application Description
          Inhibitor for transglutaminase.The molecule was developed to block coagulation factor XIIIa, however the compound inhibits tissue transglutaminase as well. Both enzymes are inhibited with an IC50 of about 0.25 μM.
      • Reference

        • Freund, K.F. et al. Biochemistry 1994, 33, 10109.
          Lorand, L. et al. Exp. Eye Res. 1998, 66, 531.
          Dale, G.L. et al. Nature 2002, 415, 175.
          Dodt, J. et al. Anal. Biochem. 2013, 439, 145.
          v.d. Akker J. et al. PLoS One 2011, 6, e23067.
          Matlung, H.L. et al. Atherosclerosis 2010, 213, 77.
          Barsigan C. et al., J. Biol. Chem. 1991, 266, 22501.
          Katt, P.W. et al. Mol. Pharmaceutics 2015, 12, 46-55.
          Aleman, M.M. et al. J. Clin. Invest. 2014, 124, 3590.
          Aleman, M.M. et al. PLoS ONE 2015, 10, e0124448.
          Kattula, S. et al. Blood Adv. 2018, 2, 25-35.
          Macrae, F.L. et al. Clin Invest. 2018, 128, 3356-3368.

    Datasheet
    MSDS

    We Also Recommend

    Coagulation factor XIII

    Coagulation factor XIII

    $1,236

    FXIII-Assay Substance

    FXIII-Assay Substance

    $980

    Guinea pig liver transglutaminase

    Guinea pig liver transglutaminase

    $826

    Human blood coagulation Factor XIII-A2

    Human blood coagulation Factor XIII-A2

    $808

    Human blood coagulation Factor XIII-A2

    Human blood coagulation Factor XIII-A2

    $767

    Human tissue transglutaminase

    Human tissue transglutaminase

    $808

    Human tissue transglutaminase

    Human tissue transglutaminase

    $808

    Human tissue transglutaminase

    Human tissue transglutaminase

    $808