Coagulation factor XIII

- Overview
  - Recombinant human Factor XIII is a homodimer (A2) composed by two chains held together by non covalent bonds. It is N-terminally fused to a hexahistidine-tag. After activation of the zymogen by Thrombin and Ca2+ to its active form (A*2, Factor XIIIa), Factor XIIIa catalyzes the formation of covalent bridges (ε-(γ-glutamyl) lysine bonds) between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is insoluble and resistant to lysis.
    
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    Background
    
    100 E*, approximates 1,000 μg FXIII-A2
    250 E*, approximates 2,500 μg FXIII-A2
    *1 E is defined as the Factor XIII activity of 1 mL citrated plasma from healthy human donors.
    
    More Details
    
    Zedira
- Properties
  - Name
    
    Recombinant fibrin stabilizing factor, protein-glutamine-γ-glutamyltransferase
    
    Source
    
    Insect cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    Contains TRIS buffered Human Serum Albumin (HSA), Glucose and Sodium chloride
    
    Storage
    
    Store at –20 °C in working aliquots. Repeated freezing and thawing is not recommended.
    
    Note
    
    INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS.
    
    Molecular Weight
    
    84 kDa (monomer); 168 kDa (homodimer)
    
    Class
    
    Human Factor XIII-A2
    
    Reconstitution
    
    Add the volume of water specified in the certificate of analysis under Aliquotation to the vial of lyophilized powder. Rotate vial gently until solid dissolves. After reconstitution the solution should be stored frozen in working aliquots. For short term storage keep cooled on ice.
    
    Activity
    
    Thrombin, Ca2+
- Applications
  - Application Description
    
    Research and development purposes