FXIII-Assay Substance

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Also suitable for TG1, TG2, TG3 and TG6
    
    More Details
    
    Zedira
- Properties
  - Purification
    
    >95 % (HPLC)
    
    Storage
    
    Store at -20°C, desiccate
    
    Note
    
    The molecular weight was corrected to 1853.95, taking into account that A101 traps only one TFA counter ion instead of two counter ions as stated in PDS RN3.1 from 07 May 2014. The presence of one TFA counter ion is valid for all former batches, too.
    Background: During the course of our continuous quality assurance process, Zedira developed a novel method to quantify the TFA counter ion content by using a 19F NMR method according to Little et al. (J. Pharm. Biomed. Anal. 2007, 43, 1324), based on an internal standard. Please note that neither the synthesis and purification nor the product as such has been changed. Please consider the molecular weight correction if necessary.Intended for research use only, not for use in human, therapeutic or diagnostic applications.
    
    Molecular Weight
    
    1853.95 (free base: 1739.92)
    
    Class
    
    Isopeptidase-Fluorogenic Assays
- Applications
  - Application Description
    
    Kinetic measurement of transglutaminases
- Reference
  - Oertel, K. et al. Anal. Biochem. 2007, 367, 152.
    Dodt, J. et al. Anal. Biochem. 2013, 439, 145.
    Berny‐Lang, M.A. et al. J. Am. Heart Assoc. 2013, 2, e000026.
    Schroeder, V. et al. Br. J. Haematol. 2015, 168, 757.
    de Jager, M. et al. Neuropathol. Appl. Neurobiol. 2016, 42, 255.
    Király, R. et al. Amino Acids 2016, 48, 31.
    van der Wildt, B. et al. Nucl. Med. Biol. 2016, 43, 232.
    Dodt, J. et al. Br. J. Haematol. 2016, 172, 452.
    Chrobok, N.L. et al. PLoS ONE 2018, 13, e0209522.
    Akbar, A. et al. J. Med. Chem. 2017, 60, 7910-7927.
    Singh, S. et al. Int. J. Mol. Sci. 2019, 20, 2682.