1,3-Dimethyl-4,5-diphenyl-2-[(2-oxopropyl)thio]imidazolium trifluorosulfonic acid salt

- Overview
  - D004 (L-683.685) is a good blocker of tissue transglutaminase and coagulation factor XIIIa. Both enzymes are blocked with an IC50 of about 0.35 μM.
    
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    More Details
    
    Zedira
- Properties
  - Molecular Weight
    
    486.53 (free cation: 337.46)
    
    Storage
    
    Store at -20°C
    
    * Intended for research use only, not for use in human, therapeutic or diagnostic applications.
- Applications
  - Application
    
    FXIII Inhibitors
    
    Application Description
    
    Inhibitior for transglutaminase.The molecule was developed to block coagulation factor XIIIa, however the compound inhibits tissue transglutaminase as well. Both enzymes are inhibited with an IC50 of about 0.35 μM.
- Reference
  - Lorand et al., Exp. Eye Res., 1998, 66:531-6
    Barsigian et al., J. Biol. Chem., 1991, 266:22501-9