Human Factor XIIIa, Thrombin activated

Human Factor XIIIa, Thrombin activated

Catalog Number:
E001055234ZED
Mfr. No.:
T070
Price:
$894
  • Size:
    200 µg
    Quantity:
    Add to Cart:
      • Overview
        • Recombinant human Factor XIII is a homodimer (a2) composed of two chains held together by non covalent bonds. After activation of the zymogen by Thrombin and Ca2+ to its active form (a*2, Factor XIIIa), Factor XIIIa catalyzes the formation of covalent bridges (ε-(γ-glutamyl) lysine bonds) between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is insoluble and resistant to lysis.

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          More Details

      • Properties
        • Name
          Recombinant Fibrin stabilizing factor
          Source
          Insect cells
          Type
          Recombinant Proteins
          Purification
          > 95% [by SDS-PAGE]
          Formulation
          The recombinant human Factor XIIIa is lyophilized from 50 mM Tris-HCl pH 7.4, 300 mM NaCl, 1 mM CHAPS, 3 mM Ca2+. Sample contains sucrose.
          Storage
          Storage for several months is possible at ≤ - 20°C. Delivery is possible at ambient temperature
          Note
          INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS.
          Molecular Weight
          78 kDa
          Class
          Human Factor XIII-A2
          Reconstitution
          Add the volume of water specified in the certificate of analysis under aliquotation to the vial of lyophilized powder. Rotate vial gently until solid dissolves. After reconstitution the solution should be stored frozen in working aliquots. For short term storage keep cooled on ice.
      • Applications
        • Application Description
          rhFXIIIa catalyzes acyl transfer reactions from glutamine residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl) lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue.
      • Reference
        • Chrobok et al., PLoS One. 2018, 13:e0196433
          Akbar et al., J. Med. Chem. 2017, 60:7910-27
          de Jager, M. et al., Neuropathol. Appl. Neurobiol. 2016, 42, 255
          Hamedani et al., Chem. Commun. 2015, 51, 1135-39
          Böhm et al,. J. Med. Chem. 2014, 57:10355-65

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