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Overview
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Emestrin is a macrocyclic mycotoxin first isolated from Emericella striata by researchers at Hoshi Unveristy, Japan in 1985. Emestrin posseses a unique epidithiodioxopiperazine ring as part of a larger heterologous macrocycle. Emestrin inhibits mitochondrial ATP synthesis via uncoupling of oxidative phosphorylation and depression of mitochondrial respiration. Emestrin is a potent antagonist of the chemokine CCR2 receptor, via inhibition of MCP-1 binding, specifically mediating monocyte chemotaxis.
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