Derquantel

- Overview
  - Derquantel is a semi-synthetic paraherquamide analog, derived from a fermentation product of Penicillium simplicissimum via chemical reduction. It is an anthelmintic spiroindole that acts as a nicotinic acetylcholine receptor antagonist. Derquantel is a potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. The compound is prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction.
    
    Derquantel is soluble in ethanol, methanol, DMF and DMSO.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Derquantel and other paraherquamides induce a flaccid paralysis in nematodes thought to be from inhibition of nicotinic acetylcholine receptors acting as an antagonist of acetylcholine.
- Properties
  - CAS Number
    
    187865-22-1
    
    Molecular Formula
    
    C28H37N3O4
    
    Molecular Weight
    
    479.6
    
    Appearance
    
    White solid
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Derquantel is active against parasitic worms.
    
    Microbiology Applications: Understanding the fundamental biology and physiology of parasites can assist in more effective compound discovery efforts. Repurposing existing compounds attractive option considering that clinical studies may have been done which could speed efforts. THe One Health approach, where insights on anthelmintic efficacy are shared between human and animal domains to advance options in both domains.