LL-37 (human) Trifluoroacetate Salt

- Overview
  - LL-37 (human) Trifluoroacetate Salt (LL-37) is a naturally-occuring antimicrobial peptide that is part of the innate host immune system. It is associated with the epidermis and protects the host from bacterial infection. LL-37 has also demonstrated a range of other bioactivity including anti-influenza, immunomodulatory, and cell death activity in certain cell types. Unlike other antimicrobial peptides, LL-37 can aggregate to protect from proteolytic degredation. This protein fibril can act as a scaffold for functional and durable biomaterials for a wide range of medical and technological applications.
    
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    Background
    
    LL-37 assumes a primarily α-helical shape during membrane interactions allowing for membrane penetration, formation of transmembrane pores and bacterial lysis.
- Properties
  - CAS Number
    
    597562-32-8
    
    Molecular Formula
    
    C205H340N60O53
    
    Molecular Weight
    
    4493.32
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: Accumulating evidence indicates that LL-37 also plays a significant role in human cancer. It has an anti-cancer effect in colon cancer, gastric cancer, hematologic malignancy and oral squamous cell carcinoma (Chen et al, 2018).