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Overview
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Nemadectin is a natural substance with broad-spectrum endectocidal, nematicidal and insecticidal activity. It is a macrocyclic lactone that is structurally similar to milbemycin and avermectin antibiotics, differing by the unsaturated side-chain extending from the 6,6-spiroketal core. This antiparasitic agent can be used as a starting material for the production of Moxidectin.
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Background
Nemadectin binds to the ion channels that are needed for invertebrate nerve and muscle cell function. This leads to an increase permeability leading to an influx of chloride ions and parasite paralysis.
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