Maduramicin

- Overview
  - Maduramicin is a monovalent glycoside polyether ionophore antibiotic and broad-spectrum anticoccidial As a ionophore, it forms complexes with monovalent cations, with a higher affinity for K+ than Na+. Maduramicin is soluble in ethanol, methanol, DMF or DMSO but exhibits poor water solubility.
    
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    Background
    
    Maduramicin can form complexes with cations (particularly Na+, K+ and Ca2+), thereby promoting their transport across the cell membrane and increasing the osmotic pressure in the coccidia, which inhibits certain mitochondrial functions such as substrate oxidation and ATP hydrolysis, eventually leading to protozoal cell death.
    In cell culture studies, Maduramicin was found to cause accumulation of the cells at G0/G1 phase of the cell cycle, and induces cellular apoptosis. It can also downregulate protein expression of cyclin D1, cyclin-dependent kinases, and upregulate expression of CDK inhibitors.
- Properties
  - CAS Number
    
    79356-08-4
    
    Molecular Formula
    
    C47H80O17
    
    Molecular Weight
    
    917.1
    
    Appearance
    
    White solid
    
    Solubility
    
    Soluble in ethanol, methanol, DMF or DMSO but poor water solubility
    
    Other Properties
    
    Source: Actinomadura yumaensis (formerly Nocardia sp. X-14868
    Purity Level: >98% by HPLC
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: It is effective against Gram-positive bacteria, and exhibits a broad spectrum of anticoccidial activity against the most frequently occurring Eimeria species, and is also active against Cryptosporidium and Treponema.
    
    Microbiology Applications: Maduramicin is currently used to combat coccidiosis in poultry.
    
    Eukaryotic Cell Culture Applications: Using mouse myoblasts (C2C12) and human rhabdomyosarcoma (RD and Rh30) cells as an experimental model, Maduramicin was found to inhibit proliferation and induce apoptosis in a dose-dependent fashion.
    A chemiluminescence immunoassay (CLIA) was developed to detect Cryptosporidium parvum growth in Madin-Darby canine kidney (MDCK) cell cultures. Maduramicin was found to have selective activity against C. parvum in a dose-dependent manner. CLIA offers advantages over conventional enzyme-linked immunosorbent assay and immunofluorescence assay methods in that it is more sensitive and efficient. It is an efficient tool for evaluating potential anti-cryptosporidial compounds prior to testing in animal models.

Datasheet

MSDS

Maduramicin

Background

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