Etamsylate

- Overview
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    Background
    
    Etamsylate is a haemostatic agent. It acts on the first step of hemostasis by improving platelet adhesiveness and restoring capillary resistance. Recent studies showed that Ethamsylate promotes P-selectin-dependent, platelet adhesive mechanisms. Haemostatic action is due to activation of thromboplastin formation on damaged sites of small blood vessels and decrease of Prostacyclin l2 synthesis.
    The exact mechanism of action is unknown. It has been shown to facilitate the aggregation of platelets mediated by a thromboxane A2 or prostaglandin F2a-dependent mechanism.
- Properties
  - CAS Number
    
    2624-44-4
    
    Molecular Formula
    
    C10H17NO5S
    
    Molecular Weight
    
    263.31
    
    Appearance
    
    White to almost white crystalline powder
    
    Solubility
    
    Soluble in water and DMSO
    
    Other Properties
    
    Source: Synthetic
    
    Storage
    
    ≤ 30 °C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: Researchers measured the expression of P-selectin in the membrane of SV40-transformed aortic rat endothelial cells. There was a significant increase in the percentage of platelets expressing P-selectin even at the lowest concentration (1 uM), with maximal enhancement at 10 uM (Alvarez-Guerra M et al, 2002).
    Etamsylate inhibited prostaglandin biosynthesis in microsomes of pregnant human myometrium with IC50 of 0.5mM. It is active against hydroxyl radicals. It potentiates human platelet aggregation and ATP release induced by arachidonic acid, thromboxane A2, collagen, and calcium inophore A23187 (Garay, 2006).