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Overview
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Tipiracil is a member of the pyrimidone class. It inhibits the enzyme thymidine phosphorylase (TPase), which is an endothelial cell growth factor. It is used in combination with Trifluidine, since it inhibits the enzyme that metabolizes trifluridine, and Trifluridine/Tipiracil is used in colorectal cancer therapy.
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Background
Tipiracil is a thymidine phosphorylase inhibitor and prevents conversion into the inactive major metabolite (5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione). Thus, the compound can increase trifluidine bioavailability in vivo.
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