Quinine Hydrochloride

- Overview
  - Quinine Hydrochloride is a naturally occurring chemical compound, an alkaloid, and potassium channel blocker. It is a stereoisomer of quinidine which contains an aromatic quinoline and a bicyclic quinuclidine. It was first isolated from the bark of a cinchona tree in 1820.
    
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    Background
    
    The mechanism of action of quinine has not been fully resolved. A closely related drug, chloroquine, is toxic to parasites by inhibiting hemozoin biocrystallization in the heme detoxification pathway, which allows buildup of cytotoxic heme which accumulates in the parasites resulting in death.
- Properties
  - CAS Number
    
    6119-47-7
    
    Molecular Formula
    
    C20H24N2O2 ∙ HCl
    
    Molecular Weight
    
    396.91
    
    Appearance
    
    White powder
    
    Solubility
    
    Water: very soluble. DMSO: very soluble.
    
    Other Properties
    
    Source: Biological; derived from cinchona tree bark
    
    Storage
    
    ≤30°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Parasites. Antimalarial.