Terbinafine Hydrochloride

- Overview
  - Terbinafine Hydrochloride (Terbinafine HCl) belongs to the allylamine class of antifungals. It is active against fungi and yeast. It is used in studies of adsorption and stability. It is used against the dematophytic fungi. It has anti-cancer properties.
    Terbinafine HCl is soluble in methanol.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Terbinafine inhibits squalene monooxygenase thus blocking ergosteriol biosynthesis, an essential component of fungal cell membranes. Inhibition results in squalene accumulation. It is lipophylic. The compound can also reduce the fungi's ability to generate reactive oxygen species.
    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for details.
- Properties
  - CAS Number
    
    78628-80-5
    
    Molecular Formula
    
    C21H25N · HCl
    
    Molecular Weight
    
    327.89
    
    Solubility
    
    Soluble in methanol
    
    Other Properties
    
    Source: Synthetic
    
    Storage
    
    <30°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Terbinafine HCl is active against fungi and yeast, specifically against dermatophytes. It is fungistatic against Candida albicans.
    
    Microbiology Applications: Terbinafine can suppress cell proliferation in vitro via inhibition of DNA synthesis and apoptosis activation (Ho et al, 2004).
    
    Eukaryotic Cell Culture Applications: Terbinafine dose-dependently decreased cell number in cultured human umbilical vascular endothelial cells (HUVEC). It was not cytotoxic at 120 mM. studies have demonstrated that Terbinafine can inhibit angiogenesis (Ho et al, 2004).
    
    Cancer Applications: Terbinafine inhibits oral squamous cell carsinoma growth in a concentration-dependent way via anti-cancer cell proliferation and anti-angiogenesis (Chien et al, 2011).