Penicillin G sodium salt, EP

- Overview
  - Penicillin is a member of the β-lactam antibiotics and was one of the first discovered antibiotics.
    Penicillin G sodium salt is sparingly soluble in aqueous solution (0.210 mg/mL).
    
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    Background
    
    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    69-57-8
    
    Molecular Formula
    
    C16H17N2NaO4S
    
    Molecular Weight
    
    356.37
    
    Appearance
    
    White or off-white powder
    
    Other Properties
    
    Source: Penicillium sp.
    PH: 5.0-7.5
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Penicillin is targets primarily Gram positive bacteria including Staphylococcus and Streptococcus species
    
    Microbiology Applications: Penicillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Streptococcus pneumoniae 0.004 µg/mL – 0.5 µg/mLStreptococcus agalactiae 0.03 µg/mL – 0.06 µg/mL Mycoplasma Media Supplements Penicillin can be used as a selective agent in several types of isolation media: Mycoplasma Agar - Mycoplasma Supplement G Mycoplasma Agar - Mycoplasma Supplement P