Name: Piperacillin Sodium Salt, USP
Price: 220.00 USD

- Overview
  - Piperacillin Sodium Salt, USP is the sodium salt form of Piperacillin, a semi-synthetic, extended spectrum fungistatic β-lactam fourth-generation ureidopenicillin. Derived from Ampicillin, Piperacillin was developed by Toyama Chemical Co, Tokyo, Japan. It has a broad spectrum activity aginsat Gram-positive and Gram-negative aerobic and anaerobic bacteria. It has greater activiity agasint β-lactamase-producing organisms compared ot the other penicillins, however is is styll hydrolysed by plasmid-mediated β-lactamases TEM-1). It can also be used to study multidrug resistance.
    Piperacillin Sodium Salt, USP is freely soluble in aqueous solution.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid-encoded β-lactamases.
- Properties
  - CAS Number
    
    59703-84-3
    
    Molecular Formula
    
    C23H26N5NaO7S
    
    Molecular Weight
    
    539.54
    
    Appearance
    
    White or off-white powder
    
    Solubility
    
    Freely soluble in aqueous solution
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): ≤ 1.0%
    PH: 5.5 to 7.5
    Assay: (Anhydrous Basis): 863 to 1007 µg/mg
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Piperacillin is a broad-spectrum antibiotic targeting a wide range of susceptible Gram-positive and Gram-negative bacteria. It targets both aerobic and anaerobic bacteria. It can be used against Enterococcus species, Pseudomonas aeruginosa, and E. coli.
    
    Microbiology Applications: Piperacillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. It is commonly used in a mixture with the beta-lactamase inhibitor Tazobactam which enhances is effectiveness. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC ranges include:
    Neisseria spp. 0.015 µg/mL – 32 µg/mL
    Bacteroides fragilis 0.25 µg/mL - 32 µg/mL
    THe MIC of Piperacilin for most strains, apart form B-lactamase strains, is little affected by increases in inoculum size up to 106 organisms/ml. Piperacillin activity decreased with increasing pH, and Mueller Hinton broth produced the most consistent results for most orgnaisms.
    
    Plant Biology Applications: Piperacillin was effective in removing background contamination in Agrobacterium-mediated plant transformation, effective against Agrobacterium tumefaciens strains LBA4404 and EHA101 in plant tissue culture experiments (Ogawa and Mii, 2004).