Nafcillin sodium salt monohydrate

- Overview
  - Nafcillin is a beta-lactamase-resistant drug of the penicillin class.
    
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    Background
    
    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    7177-50-6
    
    Molecular Formula
    
    C21H21N2O5SNa•H2O
    
    Molecular Weight
    
    454.47
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Nafcillin is targets primarily gram-positive bacteria including Staphylococcus and Streptococcus species.