Paclitaxel (Taxol)

- Overview
  - Paclitaxel (Taxol) is a unique anti-tumor agent derived from the bark of the Pacific Yew tree. The molecule consists of a complex diterpene with a taxane ring. It is a potent anti-neoplastic and anti-mitotic compound.
    Pacitaxel is sparingly soluble in ethanol, DMSO, and DMF.
    
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    Background
    
    Paclitaxel has a unique mechanism of action. In vitro, it enhances tubulin polymerization to stablize microtubules againse cold- and calcium-induced depolymerization. It is unique among chemotherapeutic agents, polymerizing tubulin in the absence of cofactors. Paclitaxel prevents tumor growth by stabilizing microtubules during mitosis in the G2/M growth phase leading to cell death.
- Properties
  - CAS Number
    
    33069-62-4
    
    Molecular Formula
    
    C47H51NO14
    
    Molecular Weight
    
    853.91
    
    Solubility
    
    Sparingly soluble in ethanol, DMSO, and DMF.
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: Paclitaxel can be used to study effects on actively dividing tumor cells.