Kasugamycin Hydrochloride

- Overview
  - Kasugamycin Hydrochloride is a salt form a Kasugamycin, is a broad-spectrum antibacterial and antifungal aminoglycoside originally isolated in 1965 from Streptomyces kasugaensis found near the Kasuga shrine in Japan. This natural product used against yeast and pathogenic fungi such as M. grisea. Kasugamycin is freely soluble in aqueous solution.
    
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    Background
    
    Like many of the known natural antibiotics, kasugamycin inhibits proliferation of bacteria by tampering with their ability to make new proteins, the ribosome being the major target. Kasugamycin inhibits protein synthesis at the step of translation initiation by direct competition with initiator transfer RNA.
- Properties
  - CAS Number
    
    19408-46-9
    
    Molecular Formula
    
    C14H25N3O9 · HCl
    
    Molecular Weight
    
    415.82
    
    Appearance
    
    White crystalline powder
    
    Solubility
    
    Freely soluble in aqueous solution
    
    Other Properties
    
    Source: Streptomyces kasugaensis
    Melting Point: 203 °C
    Purity Level: ≥73.5%
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Plant Biology Applications: In rice models, Kasugamycin is used to prevent and cure M. grisea mycelia formation with <20 µg/mL. In addition, Kasugamycin has shown to suppress a number of plant parasitic infections such as leaf spot and apple scab. Kasugamycin is preferentially used over other antifungals due to its lower phytoxicity and toxicity to animals.