Name: Josamycin
Price: 209.00 USD

- Overview
  - Josamycin is a macrolide antibiotic that inhibits protein synthesis. It has anti-cancer properties, as it is able to overcome P-glycoprotein-dependent drug resistance in cancerous tumors.
    
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    Background
    
    Josamycin inhibits peptide elongation on the ribosome by binding close to the peptidyltransferase center and blocking the peptide exit tunnel in the large ribosomal subunit. Synthesis of full-length proteins is completely shut down by Josamycin.
- Properties
  - CAS Number
    
    16846-24-5
    
    Molecular Formula
    
    C42H69NO15
    
    Molecular Weight
    
    827.99
    
    Appearance
    
    White to light yellow powder
    
    Solubility
    
    Slightly soluble in ethanol, methanol and chloroform.
    
    Other Properties
    
    Source: Streptomyces kitasatoensis and Streptomyces narbonensis var. josamyceticus.
    Purity Level: ≥95%
    
    Storage
    
    2-8°C (protect from light and moisture)
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Gram-positive bacteria
    
    Eukaryotic Cell Culture Applications: Josamycin was evaluated in cell culture with peritoneal cells and splenic cells from BALB/c mice. Phagocytic activity of C. albicans and cytokine production (IL12 and IL-18) by peritoneal cells and IL-4 production by splenic cells was evaluated, and results indicated that Josamycin acts as an immunosuppressive agent (Ortega et al, 2004).
    
    Cancer Applications: Josamycin was found to increase the accumulation of vinblastine and cyclosporine A in a dose-dependent manner in anticancer drug-resistant cells (P388/ADR). Since it inhibits the binding of vinblastine and cyclosporine A to P-glycoprotein, it may be used to overcome anticancer drug resistance. In fact, combination chemotherapy with macrolide antibiotics like Josamycin may overcome P-glycoprotein-dependent drug-resistant tumors (Wang et al, 2000).