- Overview
  - Nalidixic Acid Sodium, CulturePure® is a naphthyridone antibiotic similar in structure and mechanism to quinolones. It is an inhibitor of bacterial DNA polymerase. It was developed by Sanofi Aventis. The compound can be used for apoptosis research. The product is freely soluble in water.
    
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    Background
    
    Nalidixic Acid indirectly inhibits proteins synthesis by binding DNA and interfering with enzymes involved in DNA replication and transcription.
- Properties
  - CAS Number
    
    3374-05-8
    
    Molecular Formula
    
    C12H11N2NaO3
    
    Molecular Weight
    
    254.22
    
    Appearance
    
    White or off-white powder
    
    Solubility
    
    Water: Freely soluble (50 mg/ml)
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): ≤7.0%
    Purity Level: ≥98.0%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Nalidixic Acid is a broad-spectrum antibiotic commonly used against bacteria responsible for urinary tract infections.
    
    Microbiology Applications: Nalidixic Acid is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Escherichia coli 2 µg/mL - 8 µg/mL
    Proteus mirabilis 2.1 µg/mL - 8 µg/mL
    
    Media Supplements
    Nalidixic acid can be used as a selective agent in several types of isolation media:
    Columbia Blood Agar - Staphylococcus/Streptococcus selective supplement
    Wilkins-Chalgren Anaerobe Agar - Isolation of non-sporing anaerobes
    Wilkins-Chalgren Anaerobe Agar - Isolation of Gram-negative anaerobes
    Columbia Blood Agar - Gardnerella vaginalis Selective Supplement
    Listeria Enrichemnt Broth - Listeria Selective Enrichment Supplement
    Listeria Enrichemnt Broth - Listeria Selective Enrichment Supplements UVM I and UVM II
    Listeria Enrichment Broth - Modified Listeria Selective Enrichemnt Supplement
    Fraser Broth - Fraser Supplement
    Fraser Broth - Half Fraser Supplement
    Brucella Medium Base - Modified Brucella Selective Supplement
    Buffered Listeria Enrichment Broth - Listeria Selective Enrichment Supplement
    ChromogenicListeria Agar - ChromogenicListeria Selective Supplement
    ChromogenicListeria Agar - Chromogenic Listeria Differential Supplement