Imipenem

- Overview
  - Imipenem is a broad-spectrum β-lactam antibiotic, a carbapenem effective against extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae, a group of pathogenic microbes resistant to many first line β-lactam antibiotics and certain cephalosporins. Imipenem is a broad-spectrum antibiotic targeting a wide range of aerobic and anaerobic Gram-positive and Gram-negative bacteria. Imipenem is commonly used in susceptibility testing. Imipenem is sparingly soluble in water.
    
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    Background
    
    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Like many members of the carbapenem subgroup, imipenem is highly resistant to β-lactamase activity.
- Properties
  - CAS Number
    
    74431-23-5
    
    Molecular Formula
    
    C12H17N3O4S · H2O
    
    Molecular Weight
    
    317.36
    
    Appearance
    
    White to light yellow crystalline powder
    
    Solubility
    
    Sparingly soluble in aqueous solution
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): 5.0% - 8.0%
    Assay: (On Dried Basis): Not less than 95.0%
    Residue On Ignition: Not more than 0.2%
    Heavy Metals: Not more than 0.002%
    Optical Rotation: +84° - +89°
    
    Storage
    
    -20 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Imipenem is a broad-spectrum antibiotic targeting a wide range of aerobic and anaerobic Gram-positive and Gram-negative bacteria. Resistance to Imipenem may emerge in Pseudomonas aeruginosa.
    
    Microbiology Applications: Imipenem is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Imipenem has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Pseudomonas aeruginosa 0.25 µg/mL – 12 µg/mL
    Bacteroides fragilis 0.008 µg/mL – 1 µg/mL
    
    Plant Biology Applications: Imipenem has been shown to be effective against bacteria from the genus Burkholderia, a well described plant pathogen, and was shown to be effective for sour skin (onions), slippery skin (bulbs), and cavity disease (mushrooms)(Sojanova et al, 2007).

MSDS

Documents

MSDS-EU

Susceptibility and Resistance Data

Superbug Research Summary

Imipenem

Background

Documents

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