Herbicidin A

- Overview
  - Herbicidin A is an antibiotic with selective herbidical activity against dicots. It was originally isolated from Streptomyces saganonensis in a soil sample by Sankyo (Japan) in 1976. It is the major analog of a family of adenosine-based nucleosides containing a complex tricyclic saccharide. Herbicidin A is soluble in ethanol, methanol, DMF and DMSO.
    
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    Background
    
    The mode of action and broader pharmacology of Herbicidin A has received little attention due to its restricted availability.
- Properties
  - CAS Number
    
    55353-31-6
    
    Molecular Formula
    
    C23H29N5O11
    
    Molecular Weight
    
    551.5
    
    Appearance
    
    White to light fawn solid
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Microbiology Applications: Fermentation parameters for Herbicidin A production in submerged culture of Streptomyces scopuliridis M40 were investigated. Bioproduction was successfully scaled up from a 5-L jar to a 500-L pilot vessel (Ha et al, 2017).
    
    Plant Biology Applications: Bioherbicides include phytopathogenic microorganisms or microbial compounds useful for weed control. Bioherbicides have several advantages: 1) high specificity, 2) absence of environmental residue; and 3) reduction of resistant weed populations (Hoagland RE et al, 2007).
    Herbicidin A is both a herbicide against weeds affecting dicot plants and an antibiotic against phytopathogens.