Fumagillin

- Overview
  - Fumagillin is a polyene mycotoxin isolated from Aspergillus fumigatus in 1951 as a potent antiprotozoan for the treatment of amoebiasis. More recently, fumagillin has been shown to inhibit endothelial cell proliferation and angiogenesis.
    
    Fumagillin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
    
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    Background
    
    Fumagillin inhibits endothelial cell proliferation and angiogenesis by inhibiting methionine aminopeptidase-2 (MetAP-2).
- Properties
  - CAS Number
    
    23110-15-8
    
    Molecular Formula
    
    C26H34O7
    
    Molecular Weight
    
    458.6
    
    Appearance
    
    Yellow powder
    
    Storage
    
    -20°C
    
    * For research use only