Hygrolidin - Amerigo Scientific

- Overview
  - Hygrolidin is a 16-membered macrocyclic lactone closely related to the bafilomycins, active against Valsa ceratosperma, the pathogen of apple canker disease. Hygrolidin is active against SV40 tumor cells, and inhibits the growth of solid tumor-derived cell lines such as DLD-1 human colon cancer cells with increased cells in G1 and S phases. Hygrolidin decreases cyclin-dependent kinase (cdk) 4, cyclin D and cyclin B, and increases cyclin E and p21 levels. Hygrolidin-induced p21 inhibits cyclin A-cdk2 complex more strongly than cyclin E-cdk2 complex. It also increases p21 mRNA in DLD-1 cells, but not in normal fibroblasts.
    
    Hygrolidin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
    
    Please contact us at for specific academic pricing.
- Properties
  - CAS Number
    
    83329-73-1
    
    Molecular Formula
    
    C38H58O11
    
    Molecular Weight
    
    690.9
    
    Appearance
    
    White solid
    
    Storage
    
    -20°C
    
    * For research use only