Chlortetracycline HCl, EP

- Overview
  - Chlorotetracycline HCl, EP is tetracycline antibiotic and the first antibiotic of the tetracycline class to be discovered. Chlorotetracycline HCl is soluble at 8.6 mg/mL.
    Chlortetracycline HCl, EP meets European Pharmacopoeia (EP) specifications.
    
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    Background
    
    The mechanism of chlorotetracycline involves entering a cell and binding to the 30s ribosomal subunit preventing peptide elongation and ultimately inhibiting protein synthesis. Resistance to chlorotetracycline can be a result of inactivation by cell enzymes or pumping the antibiotic out of the cell upon entering.
- Properties
  - CAS Number
    
    64-72-2
    
    Molecular Formula
    
    C22H23ClN2O8· HCl
    
    Molecular Weight
    
    515.34 g/mol
    
    Appearance
    
    Yellow powder
    
    Other Properties
    
    Source: Streptomyces aureofaciens.
    Water Content (Karl Fischer): ≤2.0%
    PH: 2.3-3.3
    Heavy Metals: ≤50ppm
    Absorbance: A460≤0.400
    Optical Rotation: -235° to -250°
    Purity Level: >94.5%
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Chlorotetracycline is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacterial cells.
    
    Microbiology Applications: Chlorotetracycline HCl is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Micrococcus 17 µg/mL
    Plant Biology Applications: Chlortetracycline, in combination with colistin and gentamicin have been successfully used in sweet cherry (Prunus avium L). tissue culture to eliminate Pseudomonas spp. contaminants.