Fumagillin

- Overview
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    Background
    
    Antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice. Analog available, TNP 470 (Cat.No. 3750).
- Properties
  - Categories
    
    Antibiotic and antiangiogenic agent
    
    Alternative Name
    
    10-[[5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
    
    CAS Number
    
    23110-15-8
    
    Molecular Formula
    
    C26H34O7
    
    Molecular Weight
    
    458.55
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥2.58 mg/mL in EtOH with ultrasonic; ≥81.3 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C
    
    * For Research Use Only