Dog blood coagulation Factor XIII-A2

Dog blood coagulation Factor XIII-A2

Catalog Number:
E001055240ZED
Mfr. No.:
T062
Price:
$774
  • Size:
    200 µg
    Quantity:
    Add to Cart:
      • Overview
        • Recombinant dog Factor XIII is a homodimer (a2) composed of two chains held together by non covalent bonds. After activation of the zymogen by Thrombin and Ca2+ to its active form (a*2, Factor XIIIa), Factor XIIIa catalyzes the formation of covalent bridges (ε-(γ-glutamyl) lysine bonds) between fibrin units to increase the elasticity of the clot network. The resulting crosslinked fibrin is insoluble and resistant to lysis.

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          More Details

      • Properties
        • Name
          Recombinant Fibrin stabilizing factor, protein-glutamine-γ-glutamyltransferase
          Source
          Insect cells
          Type
          Recombinant Proteins
          Purification
          > 95% [by SDS-PAGE]
          Formulation
          The recombinant dog Factor XIII is lyophilized from 20 mM Tris- HCl pH 7.5, 150 mM NaCl, 1 mM EDTA, 1 mM DTT. Sample contains maltodextrin.
          Storage
          Storage for several months is possible at ≤ - 20°C. Delivery is possible at ambient temperature
          Note
          INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS.
          Molecular Weight
          83 kDa (monomer); 166 kDa (homodimer)
          Class
          Animal Factor XIII-A2
          Reconstitution
          Add the volume of H2O the protein is lyophilized from (see Certificate of Analysis) to the vial of lyophilized powder. Rotate vial gently until solid dissolves. After reconstitution the solution should be stored frozen in working aliquots. Keep cooled on ice for short term storage.
      • Applications
        • Application Description
          clFXIIIa catalyzes acyl transfer reactions from glutamine residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl) lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue.
      • Reference
        • Heil et al., Thromb. Res. 2013, 131, e214–e22

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