Tridegin

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Tridegin is a potent and highly specific inhibitor of human blood coagulation factor XIIIa that has been isolated from Haementeria ghilianii (Finney et al.,1997). T087 is a recombinant variant of Tridegin containing a carboxyterminal hexahistidine-tag.
    
    More Details
    
    Zedira
- Properties
  - Name
    
    His6-Tridegin
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    > 95% [by SDS-PAGE]
    
    Formulation
    
    Recombinant Tridegin is lyophilized from 20 mM Tris-HCl pH 8.0, 50 mM NaCl, 1 mM EDTA, 10 mg/ml sucrose
    
    Storage
    
    Storage for several months is possible at ≤ - 20°C. Delivery is possible at ambient temperature
    
    Note
    
    Intended for research use only, not for use in human, therapeutic or diagnostic applications.
    
    Molecular Weight
    
    7.5 kDa
    
    Class
    
    FXIII-Inhibitors
    
    Reconstitution
    
    Add the volume of H2O the protein is lyophilized from (see Certificate of Analysis) to the vial of lyophilized powder. Rotate vial gently until solid dissolves. After reconstitution the solution should be stored frozen in working aliquots. Keep cooled on ice for short term storage.
- Reference
  - Böhm et al., J. Med. Chem. 2014, 57:10355-65
    Finney et al., Biochem. J. 1997, 324:797-805
    Wallis et al., Blood Coagul. Fibrinolysis. 1997, 8:291-5
    Seale et al., Thromb. Haemost. 1997, 77:959-63