Clavulanate Potassium

- Overview
  - Clavulanate Potassium (Potassium Clavulanate) is a stable salt preparation of Clavulanic Acid, a natural, low-molecular weight β-lactam antibiotic. It has weak, broad-spectrum activity but offers synergistic antibacterial activity with penicillins and cephalosporins for greater efficacy against β -lactam resistant strains. The compound is an oxapenam derivative. It can be used for impurity profiling via many different methods such as capillary electrophoresis and HPLC.
    
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    Background
    
    Clavulanate is a potent suicide inhibitor of β -lactamases. It forms a covalent bond with a serine residue in the enzyme’s active site. Inhibition is time-dependent and irreversible. Clavulanic acid β-lactam antibiotics bind and inhibit PBPs (penicillin binding proteins) thus inhibiting bacterial cell wall synthesis.
- Properties
  - CAS Number
    
    61177-45-5
    
    Molecular Formula
    
    C8H8NO5K
    
    Molecular Weight
    
    237.3
    
    Appearance
    
    White to off-white powder
    
    Solubility
    
    Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
    
    Other Properties
    
    Source: Streptomyces clavuligerus
    Purity Level: >98% by HPLC
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Microbiology Applications: Clavulanic acid had poor activity against S. aureus, Enterobacteriaceae, and P. aeruginosa. However, it can act synergistically with penicillins and cephalosporins to inhibit β -lactamase-producing S. aureus and Enterobacteriaceae.