Clavulanate Lithium

- Overview
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    Background
    
    Clavulanate is a potent suicide inhibitor of β -lactamases. It forms a covalent bond with a serine residue in the enzyme’s active site. Inhibition is time-dependent and irreversible. Clavulanic acid β-lactam antibiotics bind and inhibit PBPs (penicillin binding protein) thus inhibiting bacterial cell wall synthesis.
- Properties
  - CAS Number
    
    61177-44-4
    
    Molecular Formula
    
    C8H8LiNO5
    
    Molecular Weight
    
    205.09
    
    Appearance
    
    White to light-yellow powder
    
    Other Properties
    
    Source: Streptomyces clavuligerus
    Purity Level: <95%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Weak broad-spectrum activity.
    
    Microbiology Applications: Clavulanic acid had poor activity against S. aureus, Enterobacteriaceae, and P. aeruginosa. However, it can act synergistically with penicillins and cephalosporins to inhibit β -lactamase-producing S. aureus and Enterobacteriaceae.