Amoxicillin : Potassium Clavulanate (2:1)

- Overview
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    Background
    
    Like all β-lactams, Amoxicillin targets PBP’s (penicillin binding proteins) involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised ultimately leading to the death of the cell.
- Properties
  - CAS Number
    
    Mixture
    
    Appearance
    
    Off-white or yellow powder
    
    Solubility
    
    Freely soluble in water (300 mg/ml)
    
    Other Properties
    
    PH: 4.8-8.6
    Purity Level: Amoxicillin: ≥54.0%Clavulanic Acid: ≥26.8%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Amoxicillin targets a wide range of β-lactamase negative Gram-positive and Gram-negative bacteria including E. coli and a number of Streptococcus and Staphylococcus species. Because peptidoglycan is synthesized in Gram-positive and Gram-negative bacteria, Amoxicillin can be used against a wide variety of microbes. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.
    
    Microbiology Applications: Amoxicillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Neisseria gonorrhoeae 0.3 µg/mL - 32 µg/mL
    Haemophilus influenzae 0.125 µg/mL － >64 µg/mL