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Overview
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Cefiderocol is a siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. It has in vitro activity against the non-fermenting Gram-negative bacteria causing urinary track infections. It combines a catechol-type siderophore and cephalosporin core with side chains similar to cefepime and ceftazidime.
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Background
Cefiderocol binds to iron enters the bacterial cell using the bacteria's own iron transport system. Cefiderocol acts by binding to and inhibiting penicillin-binding proteins (PBPs), preventing cell wall synthesis and ultimately causing death of the bacterial cell.
Cefiderocol can enter bacteria by binding to iron and using the bacteria's own iron-transport system to evade the bacterial porin channels. The concept of carrying compounds into other cells has been liked to the 'Trojan horse' and the siderophore technology is being explored in
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- Properties
- Applications
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Overview