Cefpodoxime, Free Acid

- Overview
  - Cefpodoxime, Free Acid, is a third-generation cephalosporin β-lactam antibiotic and a metabolite of Cefpodoxime Proxetil. Cefpodoxime, Free Acid, is soluble in DMSO.
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.
- Properties
  - CAS Number
    
    80210-62-4
    
    Molecular Formula
    
    C15H17N5O6S2
    
    Molecular Weight
    
    427.46 g/mol
    
    Appearance
    
    Brown powder
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): ≤ 5.0%
    Purity Level: ≥95.0%
    
    Storage
    
    -20°C, protect from light
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefpodoxime, Free Acid, is a broad-spectrum antibiotic which targets a wide variety of Gram-positive and Gram-negative bacteria, especially those which cause otitis media and pharyngitis.
    
    Microbiology Applications: Cefpodoxime is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include: Klebsiella pneumoniae 8 µg/mL - 64 µg/mL Haemophilus influenzae 0.032 µg/mL – 1 µg/mL