Cefpodoxime Sodium

Cefpodoxime Sodium is a broad-spectrum, semi-synthetic, third-generation cephalosporin β-lactam and bactericidal agent that interferes with the bacterial cell wall. It is effective against a wide range of Gram-positive and Gram-negative bacteria. In vivo, it is de-esterified to the free acid and active metabolite, Cefpodoxime. Cefpodoxime, patented in 1980, is stable in the presence of β-lactamase enzymes, so many organisms resistant to penicillins and cephalosporins due to their production of β-lactamase, may be susceptible to Cefpodoxime. The compound is inactivated by certain extended-spectrum β-lactamases.
Cefpodoxime Sodium is soluble in DMSO.

Please contact us at for specific academic pricing.

Background

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid-encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.