Avibactam sodium

- Overview
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    Background
    
    Avibactam sodium is a β-lactamase inhibitor that does not include the β-lactam core but maintains the capacity to covalently acylate its β-lactamase targets. Avibactam sodium inhibits β-lactamases CTX-M-15 and TEM-1, with IC50 values of 5 and 8 nM, respectively. β-Lactamases are enzymes produced by bacteria, with the ability to inactivate β-lactam antibiotics by hydrolyzing the β-lactam ring. β-Lactamases are responsible for resistance to penicillins, monobactams, carbapenems, and extended-spectrum cephalosporins. Avibactam sodium combined with β-lactam antibiotics can be potentially used for the treatment of bacterial infections comprising Gram-negative organisms.
    
    1. Ehmann DE, Jahić H, Ross PL, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(29): 11663-11668.
    2. Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clinical Microbiology Reviews, 2010, 23(1): 160-201.
    3. Berkhout J, Melchers MJ, van Mil AC, et al. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrobial Agents and Chemotherapy, 2015, 59(4): 2299-2304.
- Properties
  - Alternative Name
    
    sodium (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
    
    CAS Number
    
    1192491-61-4
    
    Molecular Formula
    
    C7H10N3NaO6S
    
    Molecular Weight
    
    287.23
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥28.7 mg/mL in DMSO; insoluble in EtOH; ≥48.2 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Avibactam sodium

Background

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