Cefpodoxime Proxetil

- Overview
  - Cefpodoxime Proxetil is a broad-spectrum, third-generation, semi-synthetic cephalosporin β-lactam antibiotic. It is an esterified cephem antibiotic that is hydrolyzed and de-esterified in vivo to its active metabolite Cefpodoxime. Cefpodoxime was patened in 1980. The dissolution of Cefpodoxime Proxetil is pH dependent. Cefpodoxime Proxetil is soluble in DMSO.
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.
- Properties
  - CAS Number
    
    87239-81-4
    
    Molecular Formula
    
    C21H27N5O9S2
    
    Molecular Weight
    
    557.60
    
    Appearance
    
    White or off-white powder
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): ≤3.0%
    Assay: (On Dried Basis): ≥96.0%
    Residue On Ignition: ≤0.2%
    Heavy Metals: ≤20ppm
    Optical Rotation: +35° to +48°
    
    Storage
    
    -20°C; Protect from light
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefpodoxime Proxetil is a broad-spectrum antibiotic which targets a wide variety of Gram-positive and Gram-negative bacteria especially those which cause otitis media and pharyngitis. It has no activity against enterococci.
    
    Microbiology Applications: Cefpodoxime is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.
    Klebsiella pneumoniae 8 µg/mL - 64 µg/mL
    Haemophilus influenzae 0.032 µg/mL – 1 µg/mL

MSDS

Cefpodoxime Proxetil

Background

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