Ceftazidime Solubilized

Ceftazidime Solubilized is a semi-synthetic, broad-spectrum, third-generation, β-lactam cephalosporin. Patented in 1978, it came into commercial use in 1984. Ceftazidime is bactericidal in action, inhibiting enzymes responsible for bacterial cell-wall synthesis, primarily penicillin binding protein 3 (PBP3). The compound is sparingly soluble in aqueous solution, but acidic and alkali solvents are commonly used to facilitate dissolution.

Please contact us at for specific academic pricing.

Background

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases, however, ceftazidime is stable in the presence of β-lactamases.